Boletín HCSBA

12 FA < 1000 Ul/L Tabla 2: FA > 1000 Ul/L FA < 1000 y Examen normal FA > 1000 y Examen normal Clínica de hepatopatía y/o TA elevadas Derivación a Gastroenterología Diagnóstico de HFTBI. Alta Repetir FA en 2 meses y pedir: Ca, P, PTH, 25 OHD 3, LDH, isoenzimas Hmga, Rx Carpo, Perfil hepático Repetir niveles FA en 2 a 4 meses Derivación a Endocrinología Sin signos enfermedad ósea y/o hepática Estudiar a familia y derivar a endocrinología Con signos enfermedad ósea y/o Ca - P anormal Exámenes de enfermedad ósea FA > 1000 Ul/L Figure 1: Age- and sex-dependent percentile charts for alkaline phosphatase activity, showing the 50 th percentile (solid lines, blue), 25 th and 75 th percentiles (dashed lines, green), 10 th and 90 th percentiles (dashdotted lines, orange), and 2.5 th and 97.5 th percentiles (dotted lines, red); the 1 st and 99 th percentiles are shown in Supplemental Figure 3 . The x-axes are scaled differently on the left- and right-hand sides of the figure to account for the dynamics in young infants; the x-axis on the right-hand side starts at 61 days. Anexo 1 noviembre 2018. Volumen 17 - N ° 74 1.- Schonhaut B. et al. Enfoque actualizado de la hiperfosfatasemia transitoria benigna de la infancia. Rev Chil Pediatr. 2017;88(1):169-175 2.- Kraut JR et al. Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new causes and a review of the literature. Am J Dis Child. 1985;139: 736-40. 3.- García Luzardo, M et al. Benign transient hyperphosphatasemia of infancy: a condition to be considered. Rev Pediatr Aten Primaria. 2012. 2;13:107-11 . 4.- Viñallonga X et al. Hiperfosfatasemia en la infancia: interpretación y actitud diagnóstica. An Pediatr Contin. 2011;9(3):176-80. 5.- Sánchez Rodríguez J et al ¿Porqué aumentan las fosfatasas alcalinas?. Aten. Primaria 2002. 29 (4): 241-245. 6.- González G et al. Asymptomatic elevation of plasmatic alkaline phosphatases secundary to benign familial hyperphosphatasemia in a patient. Rev Med Chil 1996;124:1107-10. 7.- Turan S et al. Serum Alkaline Phosphatase Levels in Healthy Children and Evaluation of Alkaline Phosphatase z-scores in Different Types of Rickets. J Clin Res Ped Endo 2011;3(1):7-11. 8.- Otero J et al. Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a “Wait and See” Approach is Optimal. Clinical Medicine Insights: Pediatrics 2011:5. 9.- Ridefelt P et al. Alkaline Phosphatase in Healthy Children: Reference Intervals and Prevalence of Elevated Levels. Horm Res Paediatr 2014;82:399-404 . 10.- Zierk J et al. Pediatric reference intervals for alkaline phosphatase. Clin Chem Lab Med 2016 ; aop. 11.- Khosrow Adeli et al. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper, Critical Reviews in Clinical Laboratory Sciences, 2017; 54:6, 358-413 . Bibliografía: