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Test de caminata de seis minutos y función
pulmonar en pacientes con bronquiolitis
obliterante post infecciosa
Iván Rodríguez N.*
,
**
,
****, Scarlett Henríquez J.**
,
*****,
Paulina Vásquez M.**
,
***** y Daniel Zenteno A.*
,
***
,
******.
Six minute walking test and pulmonary function in patients with
post infectious bronchiolitis obliterans
Introduction:
Post-infectious bronchiolitis obliterans (BO) is a chronic respiratory disease that is
established as a consequence of a lung infection produced by adenovirus. The clinical and radiological
evidence as well as spirometric variables are the cornerstones of diagnosis; however, the functional
impact of lung damage, assessed through the six minute walking test (6MWT), has been scarcely
studied in this group of patients, notwithstanding it has been recommended in the Chilean guidelines.
The aim of the study is to evaluate the correlation between spirometric variables and 6MWT perfor-
mance in patients diagnosed with BO.
Patients and Methods:
Correlation study conducted in pediatric
pulmonary rehabilitation program of Guillermo Grant Benavente Hospital from Concepción. Chile.
Records of spirometry (FEV
1
, FVC, FEV
1
/FVC and FEF
25-75
) and 6MWT (Distance walked (DW), heart
rate, oxygen saturation, dyspnea and leg fatigue) of 22 children and adolescents diagnosed with BO
were selected. The absolute values of spirometric and 6MWT variables were compared with reference
values of Knudson et al and Gatica et al respectively. Results are expressed by median and range
(maximum and minimum). In the statistical analysis, normality test (Kolmogorov-Smirnov), non-pa-
rametric test (Wilcoxon, Mann-Whitney) and correlation analysis (Rho-Spearman) were done by SPSS
11.5 with significance of p < 0.05.
Results:
The spirometry was obstructive in all patients, advanced
ventilatory limitation was found in 9 children, moderate in 4, mild in 3 and minimum in 6. The WD was
597 m (750-398), 9% below the predicted value according to age (p < 0.003). The WD was lower in
those with greater severity in spirometric impairment (p = 0.012). The WD expressed as a percentage
of predicted value showed a significant correlation with % FEV
1
(r = 0.70, p = 0.0001), FEV
1
/FVC
ratio (r = 0.58, p = 0.004) and FEF
25-75%
(r = 0.70, p = 0.0001). On the other hand only saturation
at the end of 6MWT showed significant correlation with % FVC (r = 0.44, p = 0.04).
Conclusion:
Performance during the 6MWT was positively correlated with spirometry, validating the 6MWT as a
tool to assess the functional impact of lung damage in patients with BO. Future prospective studies
are needed to evaluate the correlation between lung function and exercise tolerance in these patients.
Key words:
Six minute walking test, lung function, bronchiolitis obliterans, children.
Conflicto de interés: Los autores de la revisión declaran no poseer conflicto de interés.
*
Unidad de Ventilación Mecánica Prolongada-Programa de Rehabilitación Respiratoria Infantil. Servicio de
Pediatría. Hospital Dr. Guillermo Grant Benavente, Concepción, Chile.
** Grupo de Investigación en Kinesiología Cardiorrespiratoria. Escuela de Kinesiología, Facultad de Ciencias de
la Salud. Universidad San Sebastián. Concepción, Chile.
*** Departamento de Pediatría, Facultad de Medicina. Universidad de Concepción, Chile.
**** Kinesiólogo, Magíster en Fisiología Humana Universidad de Concepción, Alumno programa de Doctorado en
Ciencias Médicas Universidad de la Frontera Temuco, Chile.
***** Kinesióloga Universidad San Sebastián. Concepción, Chile.
******Pediatra Broncopulmonar.
Rev Chil Enf Respir 2014; 30: 68-74
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