REVISTA CHILENA DE ENFERMEDADES RESPIRATORIAS

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Cuando IP es activado por PGI2, estimula a adeni-
lato ciclasa (AC), cuya isoforma más importante
a nivel pulmonar es la AC2, incrementando los
niveles intracelulares de adenosina-monofosfato
cíclico (AMPc). Los niveles incrementados de
AMPc conllevan a la activación de la proteína
quinasa A (PKA) y posterior fosforilación de
proteínas claves. Los efectos de la PGI2 en las
células vasculares están mediados por diferentes
vías de señalización, incluyendo la vía PGI2/IP/
Gs/AMPc clásico y las vías intracrinas que impli-
can receptores nucleares34.
Agradecimientos
Los autores agradecen el apoyo financiero a
sus investigaciones otorgado por los proyectos
FONDECyT 114064, 1151119 y VID Enlace
Universidad de Chile.
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